Research workbench
Cw-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3
Analyse Cw-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O62
- Type
- protein
- Length
- 175 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger cw-type pwwp domain protein 2; Histone H3.3
- UniProt
- Q504Y3, K7ES00
- Ligands
- ZN, UNX
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 15% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Zinc finger cw-type pwwp domain protein 2 | protein | 56 | 16% helix, 13% strand | Q504Y3 |
| B | Zinc finger cw-type pwwp domain protein 2 | protein | 57 | 16% helix, 12% strand | Q504Y3 |
| D | Histone H3.3 | protein | 6 | 0% helix, 50% strand | K7ES00 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
- UNX · Unknown atom or ion · ion · 27 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.47 | 0.75 | 27 | UNX |
Interfaces
4 interfaces between chains.
- A–C · 580 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 519 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 493 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 91 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 4O62 · CW-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q504Y3 · AlphaFold monomer V2.0 prediction for zinc finger cw-type pwwp domain protein 2 (Q504Y3) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q504Y3
- Every structure of UniProt K7ES00
- Elsewhere: RCSB PDB 4O62 · PDBe 4O62 · UniProt Q504Y3 · UniProt K7ES00
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