UniProt Q504Y3
Zinc finger CW-type PWWP domain protein 2 (Q504Y3)
Zinc finger CW-type PWWP domain protein 2 (UniProt Q504Y3): 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q504Y3
- Protein
- Zinc finger CW-type PWWP domain protein 2
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 9 · 1 record with a druggable one
Structures
7 records of Q504Y3 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4O62 | CW-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 | x-ray diffraction | A, B, C | ZN, UNX | 1 (best 0.47) |
| 4O62 | Cw-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 | x-ray diffraction | A, B, C | ZN, UNX | 1 (best 0.47) |
| 4Z0O | CW-type zinc finger of ZCWPW2 with F78D mutation | x-ray diffraction | A | ZN, NA, UNX | — |
| 4Z0O | Cw-type zinc finger of ZCWPW2 with F78D mutation | x-ray diffraction | A | ZN, NA, UNX | — |
| 4Z0R | Crystal Structure of the CW domain of ZCWPW2 mutant F78R in complex with histone H3 peptide | x-ray diffraction | A, B, C | ZN, SO4, UNX | 1 (best 0.48) |
| 4Z0R | Crystal structure of the cw domain of ZCWPW2 mutant F78R in complex with histone H3 peptide | x-ray diffraction | A, B, C | ZN, SO4, UNX | 1 (best 0.48) |
| Q504Y3 | AlphaFold monomer V2.0 prediction for zinc finger cw-type pwwp domain protein 2 (Q504Y3) | predicted | A | — | 5 (best 0.64) |
Ligands
Experiment against prediction
- 4O62 chain B against the predicted model Q504Y3: TM-score 0.88, RMSD 1.17 Å
- 4O62 chain B against the predicted model Q504Y3: TM-score 0.88, RMSD 1.17 Å
- 4O62 chain A against the predicted model Q504Y3: TM-score 0.87, RMSD 1.22 Å
- 4O62 chain A against the predicted model Q504Y3: TM-score 0.87, RMSD 1.22 Å
- 4Z0R chain A against the predicted model Q504Y3: TM-score 0.87, RMSD 1.24 Å
- 4Z0R chain A against the predicted model Q504Y3: TM-score 0.87, RMSD 1.24 Å
- 4Z0O chain A against the predicted model Q504Y3: TM-score 0.86, RMSD 1.13 Å
- 4Z0O chain A against the predicted model Q504Y3: TM-score 0.86, RMSD 1.13 Å
Elsewhere
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