Research workbench

WDR5 in complex with influenza NS1 C-terminal tail

Analyse WDR5 in complex with influenza NS1 C-terminal tail in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O45
Type: protein
Length: 310 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat-containing protein 5; Nonstructural protein 1
UniProt: P61964, Q9YP60
Ligands: UNX
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat-containing protein 5	protein	305	0% helix, 51% strand	P61964
B	Nonstructural protein 1	protein	5	0% helix, 0% strand	Q9YP60

Ligands and binding sites

UNX · Unknown atom or ion · ion · 17 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	494	0.73	0.82	44	UNX
2	50	0.37	0.80	15	empty

Interfaces

1 interface between chains.

A–B · 395 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4O45 · WDR5 in complex with influenza NS1 C-terminal tail · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Every structure of UniProt Q9YP60
Elsewhere: RCSB PDB 4O45 · PDBe 4O45 · UniProt P61964 · UniProt Q9YP60

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.