Research workbench

CA2+-bound structure of multidomain ef-hand protein, CBP40, from true slime mold

Analyse CA2+-bound structure of multidomain ef-hand protein, CBP40, from true slime mold in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IJ6
Type: protein
Length: 305 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasmodial specific LAV1-2 protein
UniProt: P14725
Ligands: CA
Pockets: 3 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasmodial specific LAV1-2 protein	protein	305	67% helix, 3% strand	P14725

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	206	0.51	0.77	25	empty
2	53	0.30	0.76	13	empty
3	53	0.25	0.73	17	empty

Compared structures

1IJ6 · CA2+-bound structure of multidomain ef-hand protein, CBP40, from true slime mold · the same entry in another collection · chain A against A, TM-score 1.00
P14725 · AlphaFold monomer V2.0 prediction for plasmodial-specific protein LAV1-2 (P14725) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14725
Elsewhere: RCSB PDB 1IJ6 · PDBe 1IJ6 · UniProt P14725

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