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Crystal structure of mouse N-cadherin EC1-2 with aa insertion between residues 2 and 3

Analyse Crystal structure of mouse N-cadherin EC1-2 with aa insertion between residues… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4NUP
Type: protein
Length: 651 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N-cadherin EC1-2
UniProt: Q3UIC2
Ligands: CA
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	N-cadherin EC1-2	protein	217	5% helix, 44% strand	Q3UIC2

Ligands and binding sites

CA · Calcium ion · metal · 10 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	238	0.62	0.81	35	empty
2	279	0.59	0.78	40	empty
3	179	0.46	0.75	30	empty
4	147	0.42	0.75	32	empty
5	62	0.40	0.80	16	empty

Interfaces

2 interfaces between chains.

A–B · 1722 Å² buried · 22 hydrogen bonds · protein-protein
A–C · 466 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4NUP · Crystal structure of mouse N-cadherin EC1-2 with AA insertion between residues 2 and 3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q3UIC2
Elsewhere: RCSB PDB 4NUP · PDBe 4NUP · UniProt Q3UIC2

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