Research workbench
Crystal structure of SHP/EID1
Analyse Crystal structure of SHP/EID1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NUF
- Type
- protein
- Length
- 565 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose ABC transporter periplasmic protein, nuclear receptor subfamily 0 group B member…
- UniProt
- K0BGG6, Q62227
- Ligands
- GLC
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose ABC transporter periplasmic protein, nuclear receptor subfamily 0 group B member 2 chimeric construct | protein | 549 | 54% helix, 14% strand | K0BGG6, Q62227 |
| P | EID1 peptide | protein | 16 | 75% helix, 0% strand | — |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.71 | 0.83 | 38 | GLC |
| 2 | 121 | 0.60 | 0.86 | 27 | empty |
| 3 | 312 | 0.57 | 0.77 | 36 | empty |
| 4 | 209 | 0.46 | 0.74 | 30 | empty |
Interfaces
1 interface between chains.
- A–P · 855 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K0BGG6
- Every structure of UniProt Q62227
- Elsewhere: RCSB PDB 4NUF · PDBe 4NUF · UniProt K0BGG6 · UniProt Q62227
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.