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High-resolution structure of two tandem B domains of staphylococcal protein a connected by the conserved linker

Analyse High-resolution structure of two tandem B domains of staphylococcal protein a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4NPF
Type: protein
Length: 231 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin G-binding protein a
UniProt: P38507
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
Y	Immunoglobulin G-binding protein a	protein	116	72% helix, 0% strand	P38507
X	Immunoglobulin G-binding protein a	protein	115	73% helix, 0% strand	P38507

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.39	0.76	17	empty
2	102	0.37	0.75	17	empty

Interfaces

1 interface between chains.

Y–X · 109 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4NPF · High-resolution structure of two tandem B domains of staphylococcal protein A connected… · the same entry in another collection · chain Y against Y, TM-score 1.00
P38507 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein a (P38507) · a predicted model of the same protein · chain Y against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38507
Elsewhere: RCSB PDB 4NPF · PDBe 4NPF · UniProt P38507

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