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2.4 ångström crystal structure of an oxaliplatin 1,2-D(GPG) intrastrand cross-link in a DNA dodecamer duplex
Analyse 2.4 ångström crystal structure of an oxaliplatin 1,2-D(GPG) intrastrand… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IHH
- Type
- DNA
- Length
- 24 nucleotides
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3'; 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3'
- Ligands
- DNH, PT, BA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3' | dna | 12 | — | — |
| B | 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3' | dna | 12 | — | — |
Ligands and binding sites
- DNH · 1R,2R-diaminocyclohexane · ligand · chains A
- PT · Platinum (II) ion · metal · chains A
- BA · Barium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 573 Ų buried · 60 hydrogen bonds · nucleic-nucleic
Compared structures
- 1IHH · 2.4 ångström crystal structure of an oxaliplatin 1,2-D(GPG) intrastrand cross-link in a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1IHH · PDBe 1IHH
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