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Crystal structure of aquaporin-1

Analyse Crystal structure of aquaporin-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IH5
Type: protein
Length: 224 residues
Chains: 1
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aquaporin-1
UniProt: P29972
Pockets: 5 · best druggability 0.71

Structure

electron crystallography · 1 distinct chain · 55% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aquaporin-1	protein	224	55% helix, 0% strand	P29972

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	259	0.71	0.85	45	empty
2	55	0.48	0.86	15	empty
3	113	0.45	0.78	21	empty
4	60	0.39	0.79	16	empty
5	59	0.28	0.74	13	empty

Compared structures

1IH5 · Crystal structure of aquaporin-1 · the same entry in another collection · chain A against A, TM-score 1.00
P29972 · AlphaFold monomer V2.0 prediction for aquaporin-1 (P29972) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29972
Elsewhere: RCSB PDB 1IH5 · PDBe 1IH5 · UniProt P29972

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