Research workbench
Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP152 N-terminal fragment
Analyse Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP152… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N7V
- Type
- protein
- Length
- 477 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK4; Centrosomal protein of 152 kda
- EC
- 2.7.11.21
- UniProt
- O00444, O94986
- Pockets
- 5 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 222 | 21% helix, 32% strand | O00444 |
| C | Centrosomal protein of 152 kda | protein | 33 | 45% helix, 0% strand | O94986 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 547 | 0.74 | 0.82 | 56 | empty |
| 2 | 53 | 0.55 | 0.89 | 13 | empty |
| 3 | 83 | 0.39 | 0.78 | 18 | empty |
| 4 | 82 | 0.39 | 0.77 | 12 | empty |
| 5 | 100 | 0.39 | 0.76 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1312 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1137 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 128 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4N7V · Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152… · the same entry in another collection · chain A against A, TM-score 1.00
- O00444 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) · a predicted model of the same protein · chain A against A, TM-score 0.96
- O94986 · AlphaFold monomer V2.0 prediction for centrosomal protein of 152 kda (O94986) · a predicted model of the same protein · chain C against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00444
- Every structure of UniProt O94986
- Elsewhere: RCSB PDB 4N7V · PDBe 4N7V · UniProt O00444 · UniProt O94986
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