Research workbench
Crystal structure of the ligand binding domain (lbd) of rev-erb beta bound to cobalt protoporphyrin IX
Analyse Crystal structure of the ligand binding domain (lbd) of rev-erb beta bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N73
- Type
- protein
- Length
- 198 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor subfamily 1 group D member 2
- UniProt
- Q14995
- Ligands
- COH
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor subfamily 1 group D member 2 | protein | 198 | 66% helix, 4% strand | Q14995 |
Ligands and binding sites
- COH · Protoporphyrin IX containing co · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 393 | 0.71 | 0.82 | 41 | COH |
| 2 | 56 | 0.34 | 0.78 | 13 | empty |
| 3 | 51 | 0.33 | 0.78 | 13 | empty |
Compared structures
- 4N73 · Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14995 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 1 group D member 2… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14995
- Elsewhere: RCSB PDB 4N73 · PDBe 4N73 · UniProt Q14995
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.