Research workbench
Crystal structure of the bromo-pwwp of the mouse zinc finger mynd-type containing 11 isoform alpha in complex with histone H3.1K36ME3
Analyse Crystal structure of the bromo-pwwp of the mouse zinc finger mynd-type… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N4H
- Type
- protein
- Length
- 199 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger mynd domain-containing protein 11; Peptide from histone H3.1
- UniProt
- Q8R5C8, P68431
- Ligands
- ZN, PO4
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger mynd domain-containing protein 11 | protein | 188 | 55% helix, 16% strand | Q8R5C8 |
| B | Peptide from histone H3.1 | protein | 11 | 0% helix, 9% strand | P68431 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 215 | 0.64 | 0.82 | 22 | PEG |
| 2 | 50 | 0.27 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 659 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 4N4H · Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8R5C8 · AlphaFold monomer V2.0 prediction for zinc finger mynd domain- containing protein 11… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R5C8
- Every structure of UniProt P68431
- Elsewhere: RCSB PDB 4N4H · PDBe 4N4H · UniProt Q8R5C8 · UniProt P68431
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