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Cystal structure of cap-specific mRNA (nucleoside-2'-O-)- methyltransferase 1

Analyse Cystal structure of cap-specific mRNA (nucleoside-2'-O-)- methyltransferase 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4N4A
Type: protein
Length: 398 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
EC: 2.1.1.57
UniProt: Q8N1G2
Pockets: 7 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57)	protein	398	43% helix, 16% strand	Q8N1G2

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	489	0.74	0.83	38	empty
2	339	0.59	0.77	39	empty
3	55	0.45	0.84	16	empty
4	122	0.41	0.75	27	empty
5	51	0.29	0.76	18	empty

Compared structures

4N4A · Cystal structure of Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q8N1G2 · AlphaFold monomer V2.0 prediction for cap-specific mRNA… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N1G2
Elsewhere: RCSB PDB 4N4A · PDBe 4N4A · UniProt Q8N1G2

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