UniProt Q8N1G2
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Q8N1G2)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (UniProt Q8N1G2), EC 2.1.1.57: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 2 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8N1G2
- Protein
- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
- EC
- 2.1.1.57
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 2 · 1 record with a druggable one
Structures
10 records of Q8N1G2 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4N48 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment | x-ray diffraction | A, B | — | — |
| 4N48 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 protein in complex with capped RNA fragment | x-ray diffraction | A, B | — | — |
| 4N49 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM | x-ray diffraction | A | — | — |
| 4N49 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 protein in complex with M7GPPPG and SAM | x-ray diffraction | A | — | — |
| 4N4A | Cystal structure of Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | x-ray diffraction | A | — | — |
| 4N4A | Cystal structure of cap-specific mRNA (nucleoside-2'-O-)- methyltransferase 1 | x-ray diffraction | A | — | — |
| 8P4E | Structural insights into human co-transcriptional capping - structure 5 | electron microscopy | O | — | — |
| 8P4F | Structural insights into human co-transcriptional capping - structure 6 | electron microscopy | O | MGT, SAM | 2 (best 0.81) |
| 8W8F | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | electron microscopy | b | — | — |
| Q8N1G2 | AlphaFold monomer V2.0 prediction for cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1… | predicted | A | — | — |
Ligands
Experiment against prediction
- 4N48 chain A against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.44 Å
- 4N48 chain A against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.44 Å
- 4N49 chain A against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.55 Å
- 4N49 chain A against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.55 Å
- 4N48 chain B against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.67 Å
- 4N48 chain B against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.67 Å
- 8P4E chain O against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.97 Å
- 8P4F chain O against the predicted model Q8N1G2: TM-score 0.99, RMSD 0.97 Å
- 8W8F chain b against the predicted model Q8N1G2: TM-score 0.98, RMSD 1.41 Å
- 4N4A chain A against the predicted model Q8N1G2: TM-score 0.98, RMSD 1.24 Å
Elsewhere
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