Research workbench
Structure of importin-alpha: dutpase S11E nls mutant complex
Analyse Structure of importin-alpha: dutpase S11E nls mutant complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MZ6
- Type
- protein
- Length
- 443 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; Importin subunit alpha-1
- UniProt
- P33316, P52293
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | protein | 7 | 0% helix, 0% strand | P33316 |
| C | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial | protein | 10 | 0% helix, 0% strand | P33316 |
| E | Importin subunit alpha-1 | protein | 426 | 74% helix, 0% strand | P52293 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.47 | 0.82 | 12 | empty |
Interfaces
2 interfaces between chains.
- C–E · 693 Ų buried · 18 hydrogen bonds · protein-protein
- A–E · 482 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 4MZ6 · Structure of importin-alpha: dUTPase S11E NLS mutant complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain E against A, TM-score 0.99
- P33316 · AlphaFold monomer V2.0 prediction for deoxyuridine 5'-triphosphate nucleotidohydrolase… · a predicted model of the same protein · chain A against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33316
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 4MZ6 · PDBe 4MZ6 · UniProt P33316 · UniProt P52293
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