The form a structure of an E21Q catalytic mutant of a. thaliana IGPD2 in complex with MN2+ and a mixture of its substrate, 2R3S-igp, and an inhibitor, 2S3S-igp, to 1.12 a resolution

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 33% strand (DSSP).

Ligands and binding sites

• IG2 · (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate · ligand · chains A
• IYP · (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate · ligand · chains A
• MN · Manganese (II) ion · metal · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 4MU3 · The form A structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• O23346 · AlphaFold monomer V2.0 prediction for imidazoleglycerol-phosphate dehydratase 2… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O23346
• Elsewhere: RCSB PDB 4MU3 · PDBe 4MU3 · UniProt O23346