Research workbench
Crystal complex of RPA32C and SMARCAL1 N-terminus
Analyse Crystal complex of RPA32C and SMARCAL1 N-terminus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MQV
- Type
- protein
- Length
- 182 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication protein a 32 kda subunit; SWI/SNF-related matrix-associated actin-dependent…
- UniProt
- P15927, Q9NZC9
- Pockets
- 2 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Replication protein a 32 kda subunit | protein | 65 | 49% helix, 14% strand | P15927 |
| B, D | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a-like protein 1 | protein | 26 | 88% helix, 0% strand | Q9NZC9 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.31 | 0.76 | 13 | empty |
| 2 | 64 | 0.30 | 0.75 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–B · 613 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 576 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 489 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 23 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4MQV · Crystal complex of Rpa32c and Smarcal1 N-terminus · the same entry in another collection · chain A against A, TM-score 1.00
- P15927 · AlphaFold monomer V2.0 prediction for replication protein a 32 kda subunit (P15927) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9NZC9 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15927
- Every structure of UniProt Q9NZC9
- Elsewhere: RCSB PDB 4MQV · PDBe 4MQV · UniProt P15927 · UniProt Q9NZC9
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