Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7)

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 44% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains A, B
• MG · Magnesium ion · metal · chains A
• NH2 · Amino group · ion · chains B
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
• P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 575 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, methylation).

Compared structures

• 4MN3 · Chromodomain antagonists that target the polycomb-group methyllysine reader protein… · the same entry in another collection · chain A against A, TM-score 1.00
• O95931 · AlphaFold monomer V2.0 prediction for chromobox protein homolog 7 (O95931) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O95931
• Elsewhere: RCSB PDB 4MN3 · PDBe 4MN3 · UniProt O95931