Research workbench
Crystal structure of prefusion-stabilized rsv F variant ds
Analyse Crystal structure of prefusion-stabilized rsv F variant ds in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MMQ
- Type
- protein
- Length
- 390 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F2; Fusion glycoprotein F1 fused with fibritin trimerization domain
- UniProt
- P03420, P10104
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion glycoprotein F2 | protein | 61 | 34% helix, 44% strand | P03420 |
| B | Fusion glycoprotein F1 fused with fibritin trimerization domain | protein | 329 | 32% helix, 32% strand | P03420, P10104 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.49 | 0.84 | 17 | empty |
| 2 | 90 | 0.36 | 0.75 | 17 | empty |
| 3 | 52 | 0.27 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 3294 Ų buried · 67 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 4MMQ · Crystal Structure of Prefusion-stabilized RSV F Variant DS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03420
- Every structure of UniProt P10104
- Elsewhere: RCSB PDB 4MMQ · PDBe 4MMQ · UniProt P03420 · UniProt P10104
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