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CFTR Associated Ligand (CAL) E317A PDZ domain bound to peptide iCAL36-QDTRL (ANSRWQDTRL)

Analyse CFTR Associated Ligand (CAL) E317A PDZ domain bound to peptide iCAL36-QDTRL… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4K78
Type: protein
Length: 97 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Homo sapiens; SYNTHETIC CONSTRUCT
Molecule: Golgi-associated PDZ and coiled-coil motif-containing protein; iCAL36-QDTRL peptide
UniProt: Q9HD26

Structure

x-ray diffraction · resolution 1.8 · 2 distinct chains · 18% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Golgi-associated PDZ and coiled-coil motif-containing protein	protein	87	20% helix, 41% strand	Q9HD26
B	iCAL36-QDTRL peptide	protein	10	0% helix, 30% strand	—

Interfaces

1 interface between chains.

A–B · 622 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

4K78 · Cftr associated ligand (cal) E317A PDZ domain bound to peptide ICAL36- qdtrl (ansrwqdtrl) · the same entry in another collection · chain A against A, TM-score 1.00
Q9HD26 · AlphaFold monomer V2.0 prediction for golgi-associated PDZ and coiled-coil… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HD26
Elsewhere: RCSB PDB 4K78 · PDBe 4K78 · UniProt Q9HD26

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