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Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain

Analyse Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4I20
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.34
Source: Homo sapiens
Molecule: Epidermal growth factor receptor
EC: 2.7.10.1
UniProt: P00533
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · resolution 3.34 · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epidermal growth factor receptor (EC 2.7.10.1)	protein	287	38% helix, 19% strand	P00533

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	259	0.61	0.80	30	empty
2	214	0.56	0.78	26	empty

Compared structures

4I20 · Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 4I20 · PDBe 4I20 · UniProt P00533

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