Research workbench
Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation
Analyse Crystal structure of the human HCN4 channel C-terminus carrying the S672R… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HBN
- Type
- protein
- Length
- 199 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.6
- Source
- Homo sapiens
- Molecule
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
- UniProt
- Q9Y3Q4
- Ligands
- CMP, PO4
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · resolution 2.6 · 1 distinct chain · 51% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | protein | 199 | 51% helix, 19% strand | Q9Y3Q4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.66 | 0.87 | 25 | CMP |
| 2 | 112 | 0.38 | 0.74 | 16 | empty |
| 3 | 72 | 0.28 | 0.72 | 12 | empty |
Compared structures
- 4HBN · Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y3Q4 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3Q4
- Elsewhere: RCSB PDB 4HBN · PDBe 4HBN · UniProt Q9Y3Q4
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