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Crystal structure of putative TetR family transcriptional regulator, Fad35R, from Mycobacterium tuberculosis

Analyse Crystal structure of putative TetR family transcriptional regulator, Fad35R… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G12
Type: protein
Length: 384 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.44
Source: Mycobacterium tuberculosis
Molecule: Probable transcriptional regulatory protein (Probably TETR-FAMILY)
UniProt: O06169
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · resolution 3.44 · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Probable transcriptional regulatory protein (Probably TETR-FAMILY)	protein	192	76% helix, 0% strand	O06169

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1172	0.79	0.81	94	GOL
2	148	0.52	0.79	34	empty

Interfaces

1 interface between chains.

A–B · 1202 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

4G12 · Crystal structure of putative tetr family transcriptional regulator, FAD35R, from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O06169
Elsewhere: RCSB PDB 4G12 · PDBe 4G12 · UniProt O06169

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