MolNFT v1 · #92224 · protein
Crystal structure of putative tetr family transcriptional regulator, FAD35R, from mycobacterium tuberculosis
4G12 · Probable transcriptional regulatory protein (probably tetr…: “Crystal structure of putative tetr family transcriptional regulator, FAD35R, from mycobacterium tuberculosis”. X-ray diffraction, 2 pockets (best druggability 0.79).…
- PDB
- 4G12
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable transcriptional regulatory protein (probably tetr- family)
- UniProt
- O06169
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable transcriptional regulatory protein (probably tetr- family) | protein | 192 | 76% helix, 0% strand | O06169 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1172 | 0.79 | 0.81 | 94 | GOL |
| 2 | 148 | 0.52 | 0.79 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 1202 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4G12 · Crystal structure of putative TetR family transcriptional regulator, Fad35R, from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O06169
- Elsewhere: RCSB PDB 4G12 · PDBe 4G12 · UniProt O06169
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