Research workbench
Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide
Analyse Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CDE
- Type
- protein
- Length
- 690 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.4
- Source
- HOMO SAPIENS
- Molecule
- Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase 1 heavy chain…
- EC
- 3.4.14.1
- UniProt
- P53634
- Ligands
- U6B, NAG, CL
- Pockets
- 11 · best druggability 0.59
Structure
x-ray diffraction · resolution 2.4 · 5 distinct chains · 20% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dipeptidyl peptidase 1 exclusion domain chain (EC 3.4.14.1) | protein | 118 | 6% helix, 61% strand | P53634 |
| B | Dipeptidyl peptidase 1 heavy chain (EC 3.4.14.1) | protein | 161 | 35% helix, 14% strand | P53634 |
| C, F | Dipeptidyl peptidase 1 light chain (EC 3.4.14.1) | protein | 68 | 4% helix, 41% strand | P53634 |
| D | Dipeptidyl peptidase 1 exclusion domain chain (EC 3.4.14.1) | protein | 114 | 4% helix, 53% strand | P53634 |
| E | Dipeptidyl peptidase 1 heavy chain (EC 3.4.14.1) | protein | 161 | 34% helix, 14% strand | P53634 |
Ligands and binding sites
- U6B · 4-azanyl-N-[(2S)-1-azanylidene-3-[4-(4-cyanophenyl)phenyl]propan-2-yl]oxane-4-carboxamide · ligand · 2 copies · chains A, B, C, D, E, F
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, C, B, D, F, E
- CL · Chloride ion · ion · 2 copies · chains B, C, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.59 | 0.79 | 35 | empty |
| 2 | 183 | 0.58 | 0.81 | 25 | empty |
| 3 | 62 | 0.57 | 0.89 | 21 | U6B, CL |
| 4 | 230 | 0.53 | 0.77 | 31 | empty |
| 5 | 281 | 0.52 | 0.75 | 40 | empty |
Interfaces
11 interfaces between chains.
- E–F · 3046 Ų buried · 54 hydrogen bonds · protein-protein
- B–C · 3025 Ų buried · 59 hydrogen bonds · protein-protein
- A–B · 986 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 981 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 385 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 4 glycan, 2 covalent (disulfide, N-glycosylation, covalent ligand).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53634
- Elsewhere: RCSB PDB 4CDE · PDBe 4CDE · UniProt P53634
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