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Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A resolution
Analyse Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3P3W
- Type
- protein
- Length
- 1,482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.2
- Source
- Rattus norvegicus
- Molecule
- Glutamate receptor 3
- UniProt
- P19492
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · resolution 4.2 · 4 distinct chains · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 3 | protein | 373 | 35% helix, 20% strand | P19492 |
| B | Glutamate receptor 3 | protein | 374 | 36% helix, 20% strand | P19492 |
| C | Glutamate receptor 3 | protein | 362 | 33% helix, 22% strand | P19492 |
| D | Glutamate receptor 3 | protein | 373 | 32% helix, 21% strand | P19492 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 860 | 0.80 | 0.82 | 80 | empty |
| 2 | 535 | 0.76 | 0.84 | 53 | empty |
| 3 | 493 | 0.75 | 0.83 | 57 | empty |
| 4 | 553 | 0.74 | 0.82 | 49 | empty |
| 5 | 512 | 0.73 | 0.82 | 57 | empty |
Interfaces
4 interfaces between chains.
- B–D · 1500 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1035 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 321 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 87 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3P3W · Structure of a dimeric GLUA3 N-terminal domain (ntd) at 4.2 a resolution · the same entry in another collection · chain D against D, TM-score 1.00
- P19492 · AlphaFold monomer V2.0 prediction for glutamate receptor 3 (P19492) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19492
- Elsewhere: RCSB PDB 3P3W · PDBe 3P3W · UniProt P19492
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