Research workbench
TIE2 kinase domain
Analyse TIE2 kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FVR
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Homo sapiens
- Molecule
- Tyrosine-protein kinase tie-2
- EC
- 2.7.1.112
- UniProt
- Q02763
- Pockets
- 4 · best druggability 0.46
Structure
x-ray diffraction · resolution 2.2 · 2 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase tie-2 (EC 2.7.1.112) | protein | 299 | 39% helix, 20% strand | Q02763 |
| B | Tyrosine-protein kinase tie-2 (EC 2.7.1.112) | protein | 300 | 40% helix, 20% strand | Q02763 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.46 | 0.77 | 14 | empty |
| 2 | 89 | 0.39 | 0.77 | 22 | empty |
| 3 | 78 | 0.36 | 0.76 | 23 | empty |
| 4 | 90 | 0.34 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 467 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02763
- Elsewhere: RCSB PDB 1FVR · PDBe 1FVR · UniProt Q02763
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