Research workbench
Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion (Maltose-bound form)
Analyse Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LBS
- Type
- protein
- Length
- 748 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.15
- Source
- Escherichia coli; Homo sapiens
- Molecule
- Maltose-binding periplasmic protein, Renin receptor
- UniProt
- P0AEX9, O75787
- Ligands
- GLC
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · resolution 2.15 · 2 distinct chains · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, Renin receptor | protein | 372 | 46% helix, 20% strand | P0AEX9, O75787 |
| B | Maltose-binding periplasmic protein, Renin receptor | protein | 376 | 45% helix, 19% strand | P0AEX9, O75787 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.77 | 0.79 | 53 | empty |
| 2 | 273 | 0.70 | 0.85 | 29 | GLC |
| 3 | 290 | 0.68 | 0.83 | 33 | GLC |
| 4 | 155 | 0.41 | 0.74 | 32 | empty |
| 5 | 63 | 0.38 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1195 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3LBS · Crystal structure of the cytoplasmic tail of (PRO)RENIN receptor as a mbp fusion… · the same entry in another collection · chain A against A, TM-score 1.00
- P0AEX9 · AlphaFold monomer V2.0 prediction for MALTOSE/MALTODEXTRIN-binding periplasmic protein… · a predicted model of the same protein · chain A against A, TM-score 0.98
- O75787 · AlphaFold monomer V2.0 prediction for renin receptor (O75787) · a predicted model of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt O75787
- Elsewhere: RCSB PDB 3LBS · PDBe 3LBS · UniProt P0AEX9 · UniProt O75787
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.