Research workbench

Leukotriene A4 hydrolase in complex with dihydroresveratrol

Analyse Leukotriene A4 hydrolase in complex with dihydroresveratrol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FTU
Type: protein
Length: 606 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.9
Source: Homo sapiens
Molecule: Leukotriene A-4 hydrolase
EC: 3.3.2.6
UniProt: P09960
Ligands: RE2, ZN, YB
Pockets: 5 · best druggability 0.85

Structure

x-ray diffraction · resolution 1.9 · 1 distinct chain · 44% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leukotriene A-4 hydrolase (EC 3.3.2.6)	protein	606	44% helix, 24% strand	P09960

Ligands and binding sites

RE2 · 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol · ligand · chains A
ZN · Zinc ion · metal · chains A
YB · Ytterbium (III) ion · metal · chains A
ACT · Acetate ion · additive · chains A
IMD · Imidazole · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1066	0.85	0.86	96	ZN, RE2, IMD
2	100	0.50	0.82	19	empty
3	194	0.48	0.75	27	empty
4	135	0.45	0.77	27	empty
5	72	0.35	0.77	15	empty

Compared structures

3FTU · Leukotriene A4 hydrolase in complex with dihydroresveratrol · the same entry in another collection · chain A against A, TM-score 1.00
P09960 · AlphaFold monomer V2.0 prediction for leukotriene a-4 hydrolase (P09960) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09960
Elsewhere: RCSB PDB 3FTU · PDBe 3FTU · UniProt P09960

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