Research workbench
Plasmodium Purine Nucleoside Phosphorylase V66I-V73I-Y160F Mutant
Analyse Plasmodium Purine Nucleoside Phosphorylase V66I-V73I-Y160F Mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FOW
- Type
- protein
- Length
- 467 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.8
- Source
- Plasmodium falciparum
- Molecule
- Uridine phosphorylase, putative
- EC
- 2.4.2.3
- UniProt
- Q8I3X4
- Ligands
- IMH, PO4
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · resolution 2.8 · 2 distinct chains · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uridine phosphorylase, putative (EC 2.4.2.3) | protein | 234 | 33% helix, 31% strand | Q8I3X4 |
| B | Uridine phosphorylase, putative (EC 2.4.2.3) | protein | 233 | 33% helix, 31% strand | Q8I3X4 |
Ligands and binding sites
- IMH · 1,4-dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 283 | 0.69 | 0.84 | 39 | PO4, IMH |
| 2 | 264 | 0.67 | 0.83 | 42 | PO4, IMH |
Interfaces
1 interface between chains.
- A–B · 1922 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3FOW · Plasmodium purine nucleoside phosphorylase V66I-V73I-Y160F mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q8I3X4 · AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (Q8I3X4) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I3X4
- Elsewhere: RCSB PDB 3FOW · PDBe 3FOW · UniProt Q8I3X4
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