UniProt Q8I3X4
Uridine phosphorylase, putative (Q8I3X4)
Uridine phosphorylase, putative (UniProt Q8I3X4), EC 2.4.2.1, 2.4.2.3: 11 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 85 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8I3X4
- Protein
- Uridine phosphorylase, putative
- EC
- 2.4.2.1, 2.4.2.3
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 85 · 10 records with a druggable one
Structures
12 records of Q8I3X4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NW4 | Crystal Structure of Plasmodium falciparum Purine Nucleoside Phosphorylase in complex with ImmH and… | x-ray diffraction | A, B, C, D, E, F | SO4, IMH | 16 (best 0.79) |
| 1NW4 | Crystal structure of plasmodium falciparum purine nucleoside phosphorylase in complex with immh and… | x-ray diffraction | A, B, C, D, E, F | SO4, IMH | 16 (best 0.79) |
| 1Q1G | Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H | x-ray diffraction | A, B, C, D, E, F | SO4, MTI | 15 (best 0.79) |
| 1Q1G | Crystal structure of plasmodium falciparum pnp with 5'-methylthio- immucillin-H | x-ray diffraction | A, B, C, D, E, F | SO4, MTI | 15 (best 0.79) |
| 1SQ6 | Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase | x-ray diffraction | A | SO4 | 1 (best 0.51) |
| 1SQ6 | Plasmodium falciparum homolog of uridine PHOSPHORYLASE/PURINE nucleoside phosphorylase | x-ray diffraction | A | SO4 | 1 (best 0.51) |
| 3ENZ | Arsenolytic structure of Plasmodium falciparum purine nucleoside phosphorylase with hypoxanthine… | x-ray diffraction | A, B, C, D, E, F | HPA, R1X, ART, NA | 17 (best 0.75) |
| 3ENZ | Arsenolytic structure of plasmodium falciparum purine nucleoside phosphorylase with hypoxanthine… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3FOW | Plasmodium Purine Nucleoside Phosphorylase V66I-V73I-Y160F Mutant | x-ray diffraction | A, B | PO4, IMH | 2 (best 0.69) |
| 3FOW | Plasmodium purine nucleoside phosphorylase V66I-V73I-Y160F mutant | x-ray diffraction | A, B | — | — |
| 8W7H | Purine Nucleoside Phosphorylase in complex with MMV000848 | x-ray diffraction | A | XUH, NA, PO4 | 1 (best 0.51) |
| Q8I3X4 | AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase (Q8I3X4) | predicted | A | — | 1 (best 0.61) |
Ligands
- SO4 · Sulfate ion · in 6 records
- IMH · 1,4-dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol · in 3 records
- MTI · 3,4-dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- ART · Arsenate · in 1 record
- HPA · Hypoxanthine · in 1 record
- R1X · 1,4-anhydro-D-ribitol · in 1 record
- XUH · (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol · in 1 record
Experiment against prediction
- 1SQ6 chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.28 Å
- 1SQ6 chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.28 Å
- 3FOW chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.29 Å
- 3FOW chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.29 Å
- 3FOW chain B against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.30 Å
- 3FOW chain B against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.30 Å
- 1NW4 chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.31 Å
- 1NW4 chain A against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.31 Å
- 3ENZ chain E against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.35 Å
- 3ENZ chain E against the predicted model Q8I3X4: TM-score 1.00, RMSD 0.35 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.