Research workbench
Carboxylic ester hydrolase, single mutant h48n of bovine pancreatic pla2 enzyme
Analyse Carboxylic ester hydrolase, single mutant h48n of bovine pancreatic pla2 enzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZP4
- Type
- protein
- Length
- 123 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Bos taurus
- Molecule
- Phospholipase A2
- EC
- 3.1.1.4
- UniProt
- P00593
- Ligands
- CA, CL
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · resolution 1.9 · 1 distinct chain · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase A2 (EC 3.1.1.4) | protein | 123 | 50% helix, 9% strand | P00593 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- MRD · (4R)-2-methylpentane-2,4-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.62 | 0.85 | 25 | MRD |
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 2ZP4 · Carboxylic ester hydrolase, single mutant H48N of bovine pancreatic PLA2 enzyme · the same entry in another collection · chain A against A, TM-score 1.00
- P00593 · AlphaFold monomer V2.0 prediction for phospholipase A2 (P00593) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00593
- Elsewhere: RCSB PDB 2ZP4 · PDBe 2ZP4 · UniProt P00593
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