Research workbench
Structure of the oligomerisation domain of calcium-calmodulin dependent protein kinase II gamma
Analyse Structure of the oligomerisation domain of calcium-calmodulin dependent protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2UX0
- Type
- protein
- Length
- 815 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.46
- Source
- HOMO SAPIENS
- Molecule
- Calcium-calmodulin dependent protein kinase (cam kinase) II gamma
- EC
- 2.7.1.123
- UniProt
- Q8N4I3
- Ligands
- GLY
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.46 · 5 distinct chains · 36% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Calcium-calmodulin dependent protein kinase (cam kinase) II gamma (EC 2.7.1.123) | protein | 137 | 35% helix, 45% strand | Q8N4I3 |
| B | Calcium-calmodulin dependent protein kinase (cam kinase) II gamma (EC 2.7.1.123) | protein | 136 | 37% helix, 45% strand | Q8N4I3 |
| D | Calcium-calmodulin dependent protein kinase (cam kinase) II gamma (EC 2.7.1.123) | protein | 136 | 36% helix, 45% strand | Q8N4I3 |
| E | Calcium-calmodulin dependent protein kinase (cam kinase) II gamma (EC 2.7.1.123) | protein | 135 | 36% helix, 45% strand | Q8N4I3 |
| F | Calcium-calmodulin dependent protein kinase (cam kinase) II gamma (EC 2.7.1.123) | protein | 134 | 35% helix, 46% strand | Q8N4I3 |
Ligands and binding sites
- GLY · Glycine · ligand · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 557 | 0.72 | 0.80 | 33 | GLY |
| 2 | 532 | 0.72 | 0.80 | 33 | GLY |
| 3 | 509 | 0.71 | 0.80 | 33 | GLY |
| 4 | 506 | 0.70 | 0.80 | 34 | GLY |
| 5 | 462 | 0.69 | 0.79 | 31 | empty |
Interfaces
6 interfaces between chains.
- A–B · 591 Ų buried · 8 hydrogen bonds · protein-protein
- A–F · 590 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 585 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 585 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 576 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2UX0 · Structure of the oligomerisation domain of calcium-calmodulin dependent protein kinase II… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N4I3
- Elsewhere: RCSB PDB 2UX0 · PDBe 2UX0 · UniProt Q8N4I3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.