Research workbench
Solution NMR structure of the human ETS1/DNA complex, restrained regularized mean structure
Analyse Solution NMR structure of the human ETS1/DNA complex, restrained regularized… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2STW
- Type
- protein + DNA
- Length
- 130 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- NOT
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'); DNA…
- UniProt
- P14921
- Pockets
- 2 · best druggability 0.73
Structure
solution nmr · resolution NOT · 3 distinct chains · 35% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3') | dna | 17 | — | — |
| C | DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3') | dna | 17 | — | — |
| A | ETS1 | protein | 96 | 35% helix, 11% strand | P14921 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.73 | 0.93 | 28 | empty |
| 2 | 276 | 0.54 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–C · 786 Ų buried · 71 hydrogen bonds · nucleic-nucleic
- B–A · 545 Ų buried · 10 hydrogen bonds · protein-nucleic
- C–A · 527 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 2STW · Solution NMR structure of the human ETS1/DNA complex, restrained regularized mean… · the same entry in another collection · chain A against A, TM-score 1.00
- P14921 · AlphaFold monomer V2.0 prediction for protein C-ets-1 (P14921) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14921
- Elsewhere: RCSB PDB 2STW · PDBe 2STW · UniProt P14921
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