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Crystal structure of the repetitive segments of spectrin

Analyse Crystal structure of the repetitive segments of spectrin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2SPC
Type: protein
Length: 214 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Drosophila melanogaster
Molecule: Spectrin
UniProt: P13395
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · resolution 1.8 · 1 distinct chain · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spectrin	protein	107	91% helix, 0% strand	P13395

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.38	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 2638 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

2SPC · Crystal structure of the repetitive segments of spectrin · the same entry in another collection · chain A against A, TM-score 1.00
P13395 · AlphaFold monomer V2.0 prediction for spectrin alpha chain (P13395) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13395
Elsewhere: RCSB PDB 2SPC · PDBe 2SPC · UniProt P13395

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