MolNFT v1 · #50892 · protein

Crystal structure of the repetitive segments of spectrin

2SPC: “Crystal structure of the repetitive segments of spectrin”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #50892 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2SPC
Type: protein
Length: 214 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spectrin
UniProt: P13395
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spectrin	protein	107	91% helix, 0% strand	P13395

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.38	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 2638 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

2SPC · Crystal structure of the repetitive segments of spectrin · the same entry in another collection · chain A against A, TM-score 1.00
P13395 · AlphaFold monomer V2.0 prediction for spectrin alpha chain (P13395) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13395
Elsewhere: RCSB PDB 2SPC · PDBe 2SPC · UniProt P13395

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