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The solution structure of the p63 DNA-binding domain

Analyse The solution structure of the p63 DNA-binding domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RMN
Type: protein
Length: 233 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Tumor protein 63
UniProt: Q9H3D4
Ligands: ZN
Pockets: 1 · best druggability 0.46

Structure

solution nmr · resolution NOT · 1 distinct chain · 10% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tumor protein 63	protein	233	10% helix, 29% strand	Q9H3D4

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	167	0.46	0.75	27	empty

Compared structures

2RMN · The solution structure of the P63 DNA-binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9H3D4 · AlphaFold monomer V2.0 prediction for tumor protein 63 (Q9H3D4) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H3D4
Elsewhere: RCSB PDB 2RMN · PDBe 2RMN · UniProt Q9H3D4

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