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X-ray structure of a prolactin antagonist

Analyse X-ray structure of a prolactin antagonist in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Q98
Type: protein
Length: 191 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.7
Source: Homo sapiens
Molecule: Prolactin
UniProt: P01236
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · resolution 2.7 · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prolactin	protein	191	69% helix, 0% strand	P01236

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.38	0.76	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2Q98 · X-ray structure of a prolactin antagonist · the same entry in another collection · chain A against A, TM-score 1.00
P01236 · AlphaFold monomer V2.0 prediction for prolactin (P01236) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01236
Elsewhere: RCSB PDB 2Q98 · PDBe 2Q98 · UniProt P01236

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