MolNFT v1 · #48965 · protein

X-ray structure of a prolactin antagonist

2Q98: “X-ray structure of a prolactin antagonist”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #48965 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Q98
Type: protein
Length: 191 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prolactin
UniProt: P01236
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prolactin	protein	191	69% helix, 0% strand	P01236

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.38	0.76	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2Q98 · X-ray structure of a prolactin antagonist · the same entry in another collection · chain A against A, TM-score 1.00
P01236 · AlphaFold monomer V2.0 prediction for prolactin (P01236) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01236
Elsewhere: RCSB PDB 2Q98 · PDBe 2Q98 · UniProt P01236

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