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Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase

Analyse Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GE9
Type: protein
Length: 118 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Tyrosine-protein kinase BTK
EC: 2.7.1.112
UniProt: Q06187
Pockets: 1 · best druggability 0.56

Structure

solution nmr · resolution NOT · 1 distinct chain · 17% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase BTK (EC 2.7.1.112)	protein	118	17% helix, 25% strand	Q06187

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	280	0.56	0.76	40	empty

Compared structures

2GE9 · Solution structures of the SH2 domain of BRUTON'S tyrosine kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q06187 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (Q06187) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06187
Elsewhere: RCSB PDB 2GE9 · PDBe 2GE9 · UniProt Q06187

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