MolNFT v1 · #37840 · protein

Solution structures of the SH2 domain of BRUTON'S tyrosine kinase

2GE9 · Tyrosine-protein kinase btk: “Solution structures of the SH2 domain of BRUTON'S tyrosine kinase”. Solution nmr, 1 pocket (best druggability 0.56). MolNFT v1 #37840 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2GE9
Type: protein
Length: 118 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase btk
EC: 2.7.1.112
UniProt: Q06187
Pockets: 1 · best druggability 0.56

Structure

solution nmr · 1 distinct chain · 17% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase btk (EC 2.7.1.112)	protein	118	17% helix, 25% strand	Q06187

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	280	0.56	0.76	40	empty

Compared structures

2GE9 · Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q06187 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (Q06187) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06187
Elsewhere: RCSB PDB 2GE9 · PDBe 2GE9 · UniProt Q06187

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