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TRAP4 (engineered TRAP)

Analyse TRAP4 (engineered TRAP) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2EXT
Type: protein
Length: 195 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Geobacillus stearothermophilus
Molecule: Transcription attenuation protein mtrB
UniProt: Q9X6J6
Ligands: TRP
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · resolution 1.8 · 2 distinct chains · 0% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription attenuation protein mtrB	protein	63	0% helix, 60% strand	Q9X6J6
B, C	Transcription attenuation protein mtrB	protein	66	0% helix, 62% strand	Q9X6J6

Ligands and binding sites

TRP · Tryptophan · ligand · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.75	0.98	21	TRP
2	83	0.73	0.97	21	TRP
3	80	0.43	0.79	17	empty
4	56	0.33	0.77	12	TRP

Interfaces

2 interfaces between chains.

B–C · 1033 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 922 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2EXT · TRAP4 (engineered trap) · the same entry in another collection · chain A against A, TM-score 1.00
Q9X6J6 · AlphaFold monomer V2.0 prediction for transcription attenuation protein mtrb (Q9X6J6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X6J6
Elsewhere: RCSB PDB 2EXT · PDBe 2EXT · UniProt Q9X6J6

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