Research workbench
Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol B
Analyse Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CKP
- Type
- protein
- Length
- 279 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.05
- Source
- Homo sapiens
- Molecule
- Protein (cyclin-dependent protein kinase 2)
- EC
- 2.7.1.37
- UniProt
- P24941
- Ligands
- PVB
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · resolution 2.05 · 1 distinct chain · 36% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (cyclin-dependent protein kinase 2) (EC 2.7.1.37) | protein | 279 | 36% helix, 17% strand | P24941 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 228 | 0.65 | 0.83 | 25 | PVB, EDO |
Compared structures
- 1CKP · Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol B · the same entry in another collection · chain A against A, TM-score 1.00
- P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Elsewhere: RCSB PDB 1CKP · PDBe 1CKP · UniProt P24941
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