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Macrophage migration inhibitory factor (mif) with alanine inserted between pro-1 and met-2

Analyse Macrophage migration inhibitory factor (mif) with alanine inserted between… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CGQ
Type: protein
Length: 345 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2
Source: Homo sapiens
Molecule: Protein (macrophage migration inhibitory factor)
UniProt: P14174
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · resolution 2 · 1 distinct chain · 38% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Protein (macrophage migration inhibitory factor)	protein	115	38% helix, 32% strand	P14174

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	572	0.82	0.87	65	empty

Interfaces

3 interfaces between chains.

A–B · 1122 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 1121 Å² buried · 18 hydrogen bonds · protein-protein
B–C · 1110 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1CGQ · Macrophage migration inhibitory factor (mif) with alanine inserted between pro-1 and met-2 · the same entry in another collection · chain A against A, TM-score 1.00
P14174 · AlphaFold monomer V2.0 prediction for macrophage migration inhibitory factor (P14174) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14174
Elsewhere: RCSB PDB 1CGQ · PDBe 1CGQ · UniProt P14174

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