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Crystal structure of guanylate kinase from Plasmodium falciparum

Analyse Crystal structure of guanylate kinase from Plasmodium falciparum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Z6G
Type: protein
Length: 191 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.18
Source: Plasmodium falciparum
Molecule: guanylate kinase
EC: 2.7.4.8
UniProt: Q8I2M1
Ligands: SO4
Pockets: 1 · best druggability 0.67

Structure

x-ray diffraction · resolution 2.18 · 1 distinct chain · 42% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	guanylate kinase (EC 2.7.4.8)	protein	191	42% helix, 22% strand	Q8I2M1

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	473	0.67	0.78	38	SO4, EPE

Compared structures

1Z6G · Crystal structure of guanylate kinase from plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8I2M1
Elsewhere: RCSB PDB 1Z6G · PDBe 1Z6G · UniProt Q8I2M1

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