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Solution structure of an rRNA methyltransferase (ermam) that confers macrolide-lincosamide-streptogramin antibiotic resistance, NMR, minimized average structure

Analyse Solution structure of an rRNA methyltransferase (ermam) that confers… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YUB
Type: protein
Length: 245 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Streptococcus pneumoniae
Molecule: RRNA methyltransferase
EC: 2.1.1.48
UniProt: P21236
Pockets: 1 · best druggability 0.67

Structure

solution nmr · resolution NOT · 1 distinct chain · 31% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RRNA methyltransferase (EC 2.1.1.48)	protein	245	31% helix, 18% strand	P21236

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	282	0.67	0.82	30	empty

Compared structures

1YUB · Solution structure of an rRNA methyltransferase (ermam) that confers… · the same entry in another collection · chain A against A, TM-score 1.00
P21236 · AlphaFold monomer V2.0 prediction for rRNA adenine N-6-methyltransferase (P21236) · a predicted model of the same protein · chain A against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21236
Elsewhere: RCSB PDB 1YUB · PDBe 1YUB · UniProt P21236

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