Research workbench
Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex
Analyse Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YPQ
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.4
- Source
- Homo sapiens
- Molecule
- oxidised low density lipoprotein (lectin-like) receptor 1
- UniProt
- P78380
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · resolution 1.4 · 2 distinct chains · 17% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | oxidised low density lipoprotein (lectin-like) receptor 1 | protein | 131 | 16% helix, 34% strand | P78380 |
| B | oxidised low density lipoprotein (lectin-like) receptor 1 | protein | 135 | 17% helix, 32% strand | P78380 |
Ligands and binding sites
- DIO · 1,4-diethylene dioxide · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.56 | 0.85 | 16 | DIO |
Interfaces
1 interface between chains.
- A–B · 972 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1YPQ · Human oxidized low density lipoprotein receptor lox-1 dioxane complex · the same entry in another collection · chain A against A, TM-score 1.00
- P78380 · AlphaFold monomer V2.0 prediction for oxidized low-density lipoprotein receptor 1 (P78380) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78380
- Elsewhere: RCSB PDB 1YPQ · PDBe 1YPQ · UniProt P78380
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