Research workbench
Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution
Analyse Crystal Structure of the Complex formed between Alkaline Proteinase Savinase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TK2
- Type
- protein
- Length
- 279 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.54
- Source
- BACILLUS LENTUS; SYNTHETIC CONSTRUCT
- Molecule
- Subtilisin savinase; Gramicidin S
- EC
- 3.4.21.62
- UniProt
- P29600
- Ligands
- CA
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · resolution 1.54 · 2 distinct chains · 29% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Subtilisin savinase (EC 3.4.21.62) | protein | 269 | 30% helix, 20% strand | P29600 |
| B | Gramicidin S | protein | 10 | 0% helix, 40% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.41 | 0.81 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 537 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 d-amino, 2 modified (D-amino acid, nonstandard).
Compared structures
- 1TK2 · Crystal structure of the complex formed between alkaline proteinase savinase and… · the same entry in another collection · chain A against A, TM-score 1.00
- P29600 · AlphaFold monomer V2.0 prediction for subtilisin savinase (P29600) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29600
- Elsewhere: RCSB PDB 1TK2 · PDBe 1TK2 · UniProt P29600
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