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Cryo-EM structure of TRPM7 MHR1-3 domain

Analyse Cryo-EM structure of TRPM7 MHR1-3 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8SIB
Type: protein
Length: 454 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.62
Source: Mus musculus
Molecule: Transient receptor potential cation channel subfamily M member 7
EC: 2.7.11.1
UniProt: Q923J1
Pockets: 7 · best druggability 0.65

Structure

electron microscopy · resolution 2.62 · 1 distinct chain · 33% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1)	protein	454	33% helix, 15% strand	Q923J1

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.65	0.83	38	empty
2	269	0.55	0.77	35	empty
3	174	0.53	0.79	17	empty
4	53	0.35	0.79	14	empty
5	84	0.34	0.75	19	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

Q923J1 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q923J1
Elsewhere: RCSB PDB 8SIB · PDBe 8SIB · UniProt Q923J1

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