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Small heat shock protein from methanococcus jannaschii

Analyse Small heat shock protein from methanococcus jannaschii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SHS
Type: protein
Length: 920 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.9
Source: Methanocaldococcus jannaschii
Molecule: Small heat shock protein
UniProt: Q57733
Pockets: 12 · best druggability 0.54

Structure

x-ray diffraction · resolution 2.9 · 1 distinct chain · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Small heat shock protein	protein	115	8% helix, 50% strand	Q57733

Pockets

12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.54	0.80	32	empty
2	177	0.53	0.79	24	empty
3	183	0.53	0.79	24	empty
4	177	0.53	0.79	26	empty
5	166	0.52	0.79	23	empty

Interfaces

13 interfaces between chains.

B–D · 1769 Å² buried · 38 hydrogen bonds · protein-protein
G–H · 1761 Å² buried · 31 hydrogen bonds · protein-protein
A–C · 1757 Å² buried · 33 hydrogen bonds · protein-protein
C–G · 758 Å² buried · 10 hydrogen bonds · protein-protein
A–E · 750 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1SHS · Small heat shock protein from methanococcus jannaschii · the same entry in another collection · chain H against H, TM-score 1.00
Q57733 · AlphaFold monomer V2.0 prediction for small heat shock protein HSP16.5 (Q57733) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57733
Elsewhere: RCSB PDB 1SHS · PDBe 1SHS · UniProt Q57733

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